Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of  isolated rat heat

Kesarev, O. G.; Danilenko, L. M.; Pokrovskii, M. V.; Timokhina, A. S.; Khavanskii, A. V.

Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heat

Kesarev, O. G., Danilenko, L. M., Pokrovskii, M. V., Timokhina, A. S., Khavanskii, A. V.

Дата публикации: 2017

Дата публикации в реестре: 2020-02-28T09:19:17Z

Аннотация:

In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85 . 72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypy ridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high h eart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate

Ключевые слова:
medicine, pharmacology, 2-ethyl-6-methyl-3 hydroxypyridine succinate, doxorubicin, reperfusion, isolated heart, antioxidant

Тип: Article