The majority of people face with unfavorable influence of thermal factors of environment. The thermal trauma can be a cause of injury and death of subjects. One hundred twenty rats were subjected to influence of temperature 28, 38, 48°С in duration of 5 min in thermal camera. Brain, liver, kidneys, heart, skeletal muscles were studied with help o f light, raster and scanning electron microscopy with elemental analysis. The overheating at 38°С leaded to formation of quick adaptation to heat, directed to preservation of transport and protidosynthetic functions, as well as to development of disadaptative processes