Possible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors C7070

Dovgan, A. P.; Urojevskaya, J. S.; Khavansky, A. V.

Possible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors C7070

Dovgan, A. P., Urojevskaya, J. S., Khavansky, A. V.

Дата публикации: 2017

Дата публикации в реестре: 2020-02-28T09:24:55Z

Аннотация:

We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonist С7070. Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10). The indicated agonists of peripheral imidazoline I2receptors (C7070) significantly reducesischemically-reperfusion injury of the liver, in comparison with the preparations of moxonidine and metformine. Indirect sign of imidazoline activating mechanism of C7070 is decreasing of the hepatoprotective effect of C7070 by the preliminary administration of imidazoline receptor blocker BU-224

Ключевые слова:
medicine, pharmacology, clinical hepatology, Liver ischemia, liver reperfusion, diabetes mellitus, C7070, moxonidine, metformin, imidazoline receptor agonists

Тип: Article