Synthesis of p-tert-butylthiacalix[4]arenes functionalized with tris(2-aminoethyl)amine fragments at the lower rim and their interaction with model lipid membranes

Puplampu J.; Yakimova L.; Vavilova A.; Fayzullin D.; Zuev Y.; Stoikov I.

Synthesis of p-tert-butylthiacalix[4]arenes functionalized with tris(2-aminoethyl)amine fragments at the lower rim and their interaction with model lipid membranes

Puplampu J., Yakimova L., Vavilova A., Fayzullin D., Zuev Y., Stoikov I.

Дата публикации: 2014

Дата публикации в реестре: 2020-02-29T23:21:38Z

Аннотация:

© ISUCT Publishing. New tetrasubstituted derivatives of thiacalix[4]arene functionalized with tris(2-aminoethyl)amine fragments at the lower rim in the cone, partial cone and 1,3-alternate conformations have been synthesized. It has been shown that during the interaction of tris(2-aminoethyl)amine with thiacalix[4]arenes in cone and partial cone conformation, еру cyclic fragments are formed. The structure with acyclic fragments is obtained in the case of thiacalix[4]arenes in 1,3- alternate conformation. The interaction of these compounds with a biomembrane model system was studied. It has been shown that the interaction of these compounds with model lipid membranes depends not only on the presence of hydrophilic-hydrophobic groups but also on the spatial orientation of these groups.

Ключевые слова:
Liposomes, Membranes, Molecular recognition, Thiacalix[4]arenes

Тип: Article

Источник: SCOPUS19989539-2014-7-4-SID84923454405