КЛИНИКО-ИММУНОЛОГИЧЕСКИЕ ПАРАЛЛЕЛИ ПРИ ОСТРЫХ КИШЕЧНЫХ ИНФЕКЦИЯХ, ВЫЗВАННЫХ УСЛОВНО-ПАТОГЕННЫМИ ЭНТЕРОБАКТЕРИЯМИ

Murzabaeva, R.T.; Mavzyutov, A.R.; Valishin, D.A.; Мурзабаева, Р.Т.; Мавзютов, А.Р.; Валишин, Д.А.

КЛИНИКО-ИММУНОЛОГИЧЕСКИЕ ПАРАЛЛЕЛИ ПРИ ОСТРЫХ КИШЕЧНЫХ ИНФЕКЦИЯХ, ВЫЗВАННЫХ УСЛОВНО-ПАТОГЕННЫМИ ЭНТЕРОБАКТЕРИЯМИ

Murzabaeva, R.T., Mavzyutov, A.R., Valishin, D.A., Мурзабаева, Р.Т., Мавзютов, А.Р., Валишин, Д.А.

Дата публикации: 2018

Дата публикации в реестре: 2020-10-28T16:04:32Z

Аннотация:

Objective. To asses clinical characteristics and cytokine status of patients with acute gastrointestinal infections (AGIs) caused by opportunistic enterobacteria (OE). Patients and methods. This study included 28 patients with AGIs caused by OE aged between 18 and 50 years. We measured serum levels of proinflammatory (IL-1β, IL-6, IL-8, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10) using enzyme-linked immunosorbent assay (ELISA) in patients during the disease and in 20 healthy controls. Results. Moderate infections were diagnosed in 21 patients, whereas the remaining 7 patients had severe infections. The most common clinical variant of AGI was gastroenteritis (92.9%), whereas gastritis was observed significantly less frequently (7.1%). Comparative analysis of clinical manifestations of AGIs caused by K. pneumoniaе (64.3%), E. aerogenes (14.3%), and Proteus spp. (21.4%) demonstrated a direct correlation between the intensity of clinical symptoms and disease severity. We observed increased production of proinflammatory cytokines in the acute period with their normalization during convalescence and hyperproduction of anti-inflammatory cytokines at all stages of the disease. In the acute phase of AGI, we observed a moderate positive correlation between the levels of TNF-α, IL-1β, IL-6, IL-4, IL-10 and the severity of fever, duration of gastroenteritis, the number of red blood cells and platelets. Conclusion. Our results allows determining the significance of clinical symptoms severity, changes in the cytokine profile, and their association in order to evaluate the severity and prognosis of AGIs and to estimate the pathogenic potential of OE. © 2018, Dynasty Publishing House. All rights reserved.

Ключевые слова:
Acute gastrointestinal infections, Clinical manifestations, Cytokines, Enterobacteriaceae, Scopus

Тип: Article