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Prevention of colorectal carcinogenesis by DNA-binding small-molecule curaxin CBL0137 involves suppression of Wnt signaling

Kirsanov K., Fetisov T., Lesovaya E.A., Maksimova V., Trukhanova L., Antoshina E., Gor'kova T., Morozova O., Safina A., Fleyshman D., Salimov R., Shipaeva E., Ivanov R., Leonov A., Purmal A.A., Belitsky G.A., Gudkov A.V., Gurova K.V., Yakubovskaya M.G.

Дата публикации в реестре: 2021-08-05T20:23:59Z

Аннотация:
Ключевые слова:
1,2 dimethylhydrazine, APC protein, beta catenin, cbl 0137, heat shock transcription factor 1, interferon, Myc protein, protein inhibitor, unclassified drug, Wnt protein, animal cell, animal experiment, animal model, animal tissue, Article, colon carcinogenesis, colorectal cancer, controlled study, cytotoxicity, drug efficacy, enzyme inhibition, enzyme repression, human, human cell, in vitro study, in vivo study, luciferase assay, microarray analysis, mouse, nonhuman, priority journal, prospective study, protein expression, protein targeting, real time polymerase chain reaction, Wnt signaling

Тип: Article

Права: open access

Источник: Cancer Prevention Research

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