Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengersTerekhov S.,
Smirnov I.,
Shamborant O.,
Bobik T.,
Ilyushin D.,
Murashev A.,
Dyachenko I.,
Palikov V.,
Knorre V.,
Belogurov A.,
Ponomarenko N.,
Kuzina E.,
Genkin D.,
Masson P.,
Gabibov A. , we examine two approaches for long-acting rhBChE production: I) chemical polysialylation and II) in-
vivo Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengersTerekhov S.,
Smirnov I.,
Shamborant O.,
Bobik T.,
Ilyushin D.,
Murashev A.,
Dyachenko I.,
Palikov V.,
Knorre V.,
Belogurov A.,
Ponomarenko N.,
Kuzina E.,
Genkin D.,
Masson P.,
Gabibov A. , we examine two approaches for long-acting rhBChE production: I) chemical polysialylation and II) in-
vivo Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalizationRamirez U.,
Nikonova A.,
Liu H.,
Pecherskaya A.,
Lawrence S.,
Serebriiskii I.,
Zhou Y.,
Robinson M.,
Einarson M.,
Golemis E.,
Jaffe E. studies have identified a novel prone extracellular
tetrameric EGFR configuration, which we identify as a
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalizationRamirez U.,
Nikonova A.,
Liu H.,
Pecherskaya A.,
Lawrence S.,
Serebriiskii I.,
Zhou Y.,
Robinson M.,
Einarson M.,
Golemis E.,
Jaffe E. studies have identified a novel prone extracellular
tetrameric EGFR configuration, which we identify as a
Определение полулетальной дозы гидрохлортиазида в экспериментах in vivoЦель данного исследования – определение полулетальной дозы гидрохлортиазида в экспериментах in
vivo 3D structure of the natural tetrameric form of human butyrylcholinesterase as revealed by cryoEM, SAXS and MDBoyko K.,
Baymukhametov T.,
Chesnokov Y.,
Hons M.,
Lushchekina S.,
Konarev P.,
Lipkin A.,
Vasiliev A.,
Masson P.,
Popov V.,
Kovalchuk M. -length glycosylated
tetrameric human BChE have been unsuccessful so far. Here, a combination of three complementary
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalizationRamirez U.,
Nikonova A.,
Liu H.,
Pecherskaya A.,
Lawrence S.,
Serebriiskii I.,
Zhou Y.,
Robinson M.,
Einarson M.,
Golemis E.,
Jaffe E. studies have identified a novel prone extracellular
tetrameric EGFR configuration, which we identify as a