СИНТЕЗ ПРОИЗВОДНЫХ ПИРИМИДИН-2,4(Ш,3Щ-ДИОНОВ, СОДЕРЖАЩИХ N-АЛКИЛЬНЫЕ ЗАМЕСТИТЕЛИ

RASKILDINA, G.Z.; VALIEV, V.F.; OZDEN, I.V.; ZLOTSKII, S.S.; MESHCHERYAKOVA, S.A.; SPIRIKHIN, L.V.

СИНТЕЗ ПРОИЗВОДНЫХ ПИРИМИДИН-2,4(Ш,3Щ-ДИОНОВ, СОДЕРЖАЩИХ N-АЛКИЛЬНЫЕ ЗАМЕСТИТЕЛИ

RASKILDINA, G.Z., VALIEV, V.F., OZDEN, I.V., ZLOTSKII, S.S., MESHCHERYAKOVA, S.A., SPIRIKHIN, L.V.

Дата публикации: 2017

Дата публикации в реестре: 2021-01-19T20:38:47Z

Аннотация:

6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a mixture of N1- and N3-monosubstituted products, and the profound N-alkylation of this compound provides disubstituted uracils. The structure of the synthesized compounds was studied by H1 and 13С NMR spectroscopy and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.

Ключевые слова:
Scopus, Web of Science, 6-methyluracil, N-alkylation, gem-dichlorocyclopropane, 4-(chloromethyl)-1,3-dioxolane, antioxidant properties, ВАК

Тип: Article