SYNTHESIS OF PYRINIDINE-2,4(1Н,3Н)-DIONE DERIVATIVES CONTAINING N-ALKYL SUBSTITUENTS

Raskildinaa, G.Z.; Valieva, V.F.; Ozdena, I.V.; Meshcheryakova, S.A.; Spirikhin, L.V.; Zlotskiia, S.S.

SYNTHESIS OF PYRINIDINE-2,4(1Н,3Н)-DIONE DERIVATIVES CONTAINING N-ALKYL SUBSTITUENTS

Raskildinaa, G.Z., Valieva, V.F., Ozdena, I.V., Meshcheryakova, S.A., Spirikhin, L.V., Zlotskiia, S.S.

Дата публикации: 2017

Дата публикации в реестре: 2021-01-19T20:40:23Z

Аннотация:

6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a mixture of N1 - and N3 -monosubstituted products, and the profound N-alkylation of this compound provides disubstituted uracils. The structure of the synthesized compounds was studied by H1 and 13С NMR spectroscopy and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.

Ключевые слова:
6-methyluracil, N-alkylation, gem-dichlorocyclopropane, 4-(chloromethyl)-1,3-dioxolane, antioxidant properties

Тип: Article