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A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis, antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small-molecule drugs
Role of PPARs in progression of anxiety: Literature analysis and signaling pathways reconstruction was performed in Pathway Studio. Current study revealed 14 PPAR-regulated proteins linked to anxiety. Possible
Evaluation of Adamantane Derivatives as Inhibitors of Dengue Virus mRNA Cap Methyltransferase by Docking and Molecular Dynamics Simulations) method to verify the docking results. The MD/LIE binding free energies of selected protein
AlphaFold for a medicinal chemist: tool or toy?The development of novel small drug molecules is a complex and important cross-disciplinary task
Lysozyme-Based Composite Drug Preparations for Inhalation Administration for the production of the protein matrix-based systems for the inhalation delivery of poorly water-soluble drugs.
Two novel regulators of N-acetyl-galactosamine utilization pathway and distinct roles in bacterial infections that AgaR2 (AgaR1) binds the predicted palindromes, and the combined in vivo data from reverse
Id-1 promotes reendothelialization in the early phase after vascular injury through activation of nfkb/survivin signaling pathway restenosis. Id1 (inhibitor of DNA binding/differentiation factor 1) plays an important role in promoting cell
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization potential target for drug discovery. Methods: Our focus is on the prone EGFR tetramer, which contains a
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