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A study of systems for delivering antigens and plasmid DNA for intranasal immunization against tick-borne encephalitis virus infections. The main idea of the research: Intranasal immunization inducing mucosal and systemic immune
Prevention of Influenza A(H7N9) and Bacterial Infections in Mice Using Intranasal Immunization With Live Influenza Vaccine and the Group B Streptococcus Recombinant Polypeptides influenza infection followed by GBS burden. Mice were intranasally immunized using 107 50% egg infectious
Rapid high-yield expression of a candidate influenza vaccine based on the ectodomain of M2 protein linked to flagellin in plants using viral vectors) was achieved with the PVX-based expression system. Intranasal immunization of mice with purified Flg-4M protein
The Effect of Preexisting Immunity on Virus Detection and Immune Responses in a Phase II, Randomized Trial of a Russian-Backbone, Live, Attenuated Influenza Vaccine in Bangladeshi Children with no prior influenza vaccine exposure were randomized to receive a single intranasally-administered dose
Preclinical evaluation of a replication-deficient intranasal ΔNS1 H5N1 influenza vaccine animal models confirmed the safety and immunogenicity of the vaccine. Intranasal immunization protected
Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1 and local antibody response after the intranasal immunization of mice. Conclusion/Significance: Our finding
INTRANASAL IMMUNIZATION with A RECOMBINANT PROTEIN BASED on the M2e PEPTIDE and SECOND SUBUNIT of INFLUENZA A VIRAL HEMAGGLUTININ FRAGMENT INDUCES A CROSS-PROTECTIVE HUMORAL and T CELL RESPONSE in MICE [ИНТРАНАЗАЛЬНАЯ ИММУНИЗАЦИЯ РЕКОМБИНАНТНЫМ БЕЛКОМ НА ОСНОВЕ М2е-ПЕПТИДА И ФРАГМЕНТА ВТОРОЙ СУБЪЕДИНИЦЫ ГЕМАГГЛЮТИНИНА ВИРУСОВ ГРИППА А ИНДУЦИРУЕТ КРОСС-ПРОТЕКТИВНЫЙ ГУМОРАЛЬНЫЙ И Т-КЛЕТОЧНЫЙ ОТВЕТ У МЫШЕЙ]. Mice were immunized intranasally three times with two-week intervals. Two weeks after the final
H7N9 live attenuated influenza vaccine is highly immunogenic, prevents virus replication, and protects against severe bronchopneumonia in ferrets and evaluated in ferrets an intranasal live attenuated influenza vaccine (LAIV) against H7N9 based on the A
Mast cell degranulation and histamine release during A/H5N1 influenza infection in influenza-sensitized miceHere we evaluate the role of mast cells in infection with influenza A/H5N1 virus in immunized mice
IMMUNOPATHOGENESIS AND PERSPECTIVES FOR IMMUNOTHERAPY OF CORONAVIRUS INFECTION clinical manifestations and death. COVID-19 immunopathogenesis is linked with dysregulated immune response
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