Involvement of PI3K, MAPK ERK1/2 and p38 in functional stimulation of mesenchymal progenitor cells by alkaloid songorine

Zyuzkov, G. N.; Miroshnichenko, L. A.; Udut, E. V.; Chaikovskii, A. V.; Simanina, E. V.; Danilets, M. G.; Minakova, M. Yu.; Udut, V. V.; Tolstikova, T. G.; Zhdanov, V. V.; Shults, E. E.; Stavrova, L. A.; Burmina, Ya. V.; Dygai, A. M.

Involvement of PI3K, MAPK ERK1/2 and p38 in functional stimulation of mesenchymal progenitor cells by alkaloid songorine

Zyuzkov, G. N., Miroshnichenko, L. A., Udut, E. V., Chaikovskii, A. V., Simanina, E. V., Danilets, M. G., Minakova, M. Yu., Udut, V. V., Tolstikova, T. G., Zhdanov, V. V., Shults, E. E., Stavrova, L. A., Burmina, Ya. V., Dygai, A. M.

Дата публикации: 2015

Дата публикации в реестре: 2020-03-03T19:22:45Z

Аннотация:

We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation.

Ключевые слова:
клетки-предшественники, мезенхимальные клетки

Тип: статьи в журналах

Источник: Bulletin of experimental biology and medicine. 2015. Vol. 159, № 1. P. 58-61