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Novel Copper-Containing Cytotoxic Agents Based on 2-Thioxoimidazolones

Krasnovskaya O.O., Guk D.A., Naumov A.E., Nikitina V.N., Semkina A.S., Vlasova K.Y., Pokrovsky V., Ryabaya O.O., Karshieva S.S., Skvortsov D.A., Zhirkina I.V., Shafikov R.R., Gorelkin P.V., Vaneev A.N., Erofeev A.S., Mazur D.M., Tafeenko V.A., Pergushov V.I., Melnikov M.Y., Soldatov M.A., Shapovalov V.V., Soldatov A.V., Akasov R.A., Gerasimov V.M., Sakharov D.A., Moiseeva A.A., Zyk N.V., Beloglazkina E.K., Majouga A.G.

Дата публикации в реестре: 2021-08-05T21:16:36Z

Аннотация:
Ключевые слова:
antineoplastic agent, coordination compound, copper, imidazole derivative, imidazolone, ligand, reactive oxygen metabolite, telomerase, apoptosis, biological model, chemistry, conformation, DNA damage, drug effect, human, MCF-7 cell line, metabolism, multicellular spheroid, oxidation reduction reaction, structure activity relation, X ray crystallography, Antineoplastic Agents, Apoptosis, Coordination Complexes, Copper, Crystallography, X-Ray, DNA Damage, Humans, Imidazoles, Ligands, MCF-7 Cells, Models, Biological, Molecular Conformation, Oxidation-Reduction, Reactive Oxygen Species, Spheroids, Cellular, Structure-Activity Relationship, Telomerase

Тип: Article

Права: open access

Источник: Journal of Medicinal Chemistry

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