Особенности системы гемостаза у беременных с гипертензивными расстройствами, проживающих в высокогорных условиях Республики Таджикистан

Tadzhiboeva, N. A.; Yashchuk, A.G.; Fatkullina, I.B.; Galeeva, S.A.; Lazareva, A. Y.; Stetsenko, N. A.; Sitdikova, D.G.; Таджибоева, Н.А.; Ящук, А.Г.; Фаткуллина, И.Б.; Галеева, С.А.; Лазарева, А.Ю.; Стеценко, Н.А.; Ситдикова, Д.Г.

Особенности системы гемостаза у беременных с гипертензивными расстройствами, проживающих в высокогорных условиях Республики Таджикистан

Tadzhiboeva, N. A., Yashchuk, A.G., Fatkullina, I.B., Galeeva, S.A., Lazareva, A. Y., Stetsenko, N. A., Sitdikova, D.G., Таджибоева, Н.А., Ящук, А.Г., Фаткуллина, И.Б., Галеева, С.А., Лазарева, А.Ю., Стеценко, Н.А., Ситдикова, Д.Г.

Дата публикации: 2022

Дата публикации в реестре: 2022-10-06T23:26:28Z

Аннотация:

Introduction. Hypertensive disorders during pregnancy represent one of the pressing issues in modern obstetrics. Pregnant women living in highlands are exposed to adverse factors, the most important of which is lowered air oxygen level. Hypertension of pregnant women in high altitude conditions is accompanied with exogenous hypobaric hypoxia, leading to functional and morphological changes in all organs and systems as whole-body pathology. Aim: to study hemostasis features in pregnant women with hypertensive disorders in highlands. Materials and Мethods. A prospective comparative study enrolled 114 pregnant women with hypertensive disorders, which were divided into 2 groups: group 1 - 63 pregnant women living in highlands, and group 2 - 51 pregnant women living in lowlands. In group 1 and group 2, 42 (66,7 %) and 24 (47,0 %) pregnant women, respectively, were diagnosed with severe preeclampsia. Hemostasis parameters were examined including blood clotting time, prothrombin index, level of serum fibrinogen and soluble fibrin-monomer complexes (SFMC), international normalized ratio (INR), activated partial thromboplastin time (APTT) index, thrombin time, and platelet count. Results. Pregnant mountaineers vs. pregnant lowlanders were found to have higher level of hemostasis parameters such as APTT index (1.654 ± 0.426 vs. 0.892 ± 0.1145; p < 0.001) and SFMC level (4.921 ± 0.753 mg% vs. 3.590 ± 0.5676 mg%; p < 0.001), and thrombin time (103.206 ± 3.734 seconds vs. 93.920 ± 7.8268 seconds; p < 0.001) as well as lower fibrinogen concentration (3.762 ± 0.809 g/l vs. 4.160 ± 1.3015 g/l; p = 0.048). Conclusion. Pregnant women living in highlands vs. lowlands accompanied with severe forms of preeclampsia (66,7 % vs. 47,0 %) lose signs of hypercoagulation typical to normal pregnancy, whereas, on the contrary, iso- and hypocoagulation emerge. © 2022 Obstetrics, Gynecology and Reproduction. All rights reserved.