Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer), diseases that have no effective therapy. Here, we show that ARID1A mutation confers sensitivity to pan-
HDAC Diaryl Pyrazoline, 1,3,4-Oxadizole, and 1,2,4-Triazole Pharmacophore Hybridization: Design, Synthesis, HDAC Inhibition, and Caspase 3/7 Activation Studies characterized. The compounds were tested for
HDAC inhibitory properties on
HDAC4 and
HDAC8 isoforms, with a