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In Silico Activity Prediction and Docking Studies of the Binding Mechanisms of Levofloxacin Structure Derivatives to Active Receptor Sites of Bacterial Type IIA Topoisomerases structurally different forms of levofloxacin (Lvf) with bacterial topoisomerases targets of type IIA (DNA

STEREOSELECTIVE SYNTHESIS OF 11-PHENYLUNDECA-5Z,9Z-DIENOIC ACID AND INVESTIGATION OF ITS HUMAN TOPOISOMERASE I AND IIA INHIBITORY ACTIVITY inhibitory activity of the synthesized acid with respect to human topoisomerase I (hTop1) and II (hTop2a

STEREOSELECTIVE SYNTHESIS OF 11-PHENYLUNDECA-5Z,9Z-DIENOIC ACID AND INVESTIGATION OF ITS HUMAN TOPOISOMERASE I AND IIA INHIBITORY ACTIVITY inhibitory activity of the synthesized acid with respect to human topoisomerase I (hTop1) and II (hTop2a

NZ,(N + 4)Z-DIENOIC FATTY ACIDS: A NEW METHOD FOR THE SYNTHESIS AND INHIBITORY ACTION ON TOPOISOMERASE I AND IIA acids on the human topoisomerase I and II was studied. Resorting to the data of molecular docking, a

NZ,(N + 4)Z-DIENOIC FATTY ACIDS: A NEW METHOD FOR THE SYNTHESIS AND INHIBITORY ACTION ON TOPOISOMERASE I AND IIA acids on the human topoisomerase I and II was studied. Resorting to the data of molecular docking, a

NZ,(N + 4)Z-DIENOIC FATTY ACIDS: A NEW METHOD FOR THE SYNTHESIS AND INHIBITORY ACTION ON TOPOISOMERASE I AND IIA topoisomerase I and II was studied. Resorting to the data of molecular docking, a probable mechanism

NZ,(N + 4)Z-DIENOIC FATTY ACIDS: A NEW METHOD FOR THE SYNTHESIS AND INHIBITORY ACTION ON TOPOISOMERASE I AND IIA topoisomerase I and II was studied. Resorting to the data of molecular docking, a probable mechanism

CATALYTIC CYCLOMETALLATION IN STEROID CHEMISTRY III1: SYNTHESIS OF STEROIDAL DERIVATIVES OF 5Z,9Z-DIENOIC ACID AND INVESTIGATION OF ITS HUMAN TOPOISOMERASE I INHIBITORY ACTIVITY step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found.

CATALYTIC CYCLOMETALLATION IN STEROID CHEMISTRY III1: SYNTHESIS OF STEROIDAL DERIVATIVES OF 5Z,9Z-DIENOIC ACID AND INVESTIGATION OF ITS HUMAN TOPOISOMERASE I INHIBITORY ACTIVITY step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found.

ADVANCES IN THE CHEMISTRY OF NATURAL AND SEMISYNTHETIC TOPOISOMERASE I/II INHIBITORS studies in this field have shown that topoisomerases I and II are one of the main molecular targets

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