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The potential of influenza HA-specific immunity in mitigating lethality of postinfluenza pneumococcal infections infection with vaccine matched or mismatched influenza strains and secondary bacterial replication

Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypesBackground: Current influenza vaccines are mainly strain-specific and have limited efficacy

Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia as “mixing vessels” for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A

Amino acids in hemagglutinin antigenic site B determine antigenic and receptor binding differences between A(H3N2)v and ancestral seasonal H3N2 influenza viruses. circulating H3N2 strains. A reference A(H3N2)v virus, A/Minnesota/11/2010 (MN/10), and a seasonal H3N2 strain

Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication influenza viruses. TZV was also effective against a rimantadine-resistant influenza virus strain and against

New personalized genetic mouse model of Lesch-Nyhan syndrome for pharmacology and gene therapyIn the current study, we present the results of the generation of a genetically modified mouse

Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice significantly inhibited virus replication in mouse organs, prevented the spread of H5N1 viruses beyond

Construction and immunogenicity of a novel multivalent vaccine prototype based on conserved influenza virus antigens seasonal influenza variants, but also zoonotic and emerging pandemic influenza strains are urgently needed

Rapid high-yield expression of a candidate influenza vaccine based on the ectodomain of M2 protein linked to flagellin in plants using viral vectors conserved among human influenza A strains. However, native M2e is poorly immunogenic, but its immunogenicity

Protection against multiple influenza a virus strains induced by candidate recombinant vaccine based on heterologous m2e peptides linked to flagellinProtection against multiple influenza a virus strains induced by candidate recombinant vaccine

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