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Synthesis and initial in vitro evaluation of PSMA-targeting ligands with a modified aromatic moiety at the lysine ε-nitrogen atom
Zyk N.Y., Ber A.P., Nimenko E.A., Shafikov R.R., Evteev S.A., Petrov S.A., Uspenskaya A.A., Dashkova N.S., Ivanenkov Y.A., Skvortsov D.A., Beloglazkina E.K., Majouga A.G., Machulkin A.E.
high selectivity and nanomolar IC50 values. We synthesized and tested two conjugates with a fluorescent
Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin e Conjugate
Machulkin A.E., Uspenskaya A.A., Zyk N.U., Nimenko E.A., Ber A.P., Petrov S.A., Polshakov V.I., Shafikov R.R., Skvortsov D.A., Plotnikova E.A., Pankratov A.A., Smirnova G.B., Borisova Y.A., Pokrovsky V.S., Kolmogorov V.S., Vaneev A.N., Khudyakov A.D., Chepikova O.E., Kovalev S., Erofeev A., Gorelkin P., Beloglazkina E.K., Zyk N.V., Khazanova E.S., Majouga A.G., Zamyatnin Jr A.A.
is chemotherapy, which has a wide range of side effects. One of the solutions to this challenge is targeted
PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation
Machulkin A.E., Uspenskaya A.A., Zyk N.Y., Nimenko E.A., Ber A.P., Petrov S.A., Shafikov R.R., Skvortsov D.A., Smirnova G.B., Borisova Y.A., Pokrovsky V.S., Kolmogorov V.S., Vaneev A.N., Ivanenkov Y.A., Khudyakov A.D., Kovalev S.V., Erofeev A.S., Gorelkin P.V., Beloglazkina E.K., Zyk N.V., Khazanova E.S., Majouga A.G.
based on the drug docetaxel and synthesized a series of three docetaxel conjugates. In vitro
Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate
Machulkin Aleksei E., Nimenko Ekaterina A., Zyk Nikolay U., Uspenskaia Anastasiia A., Smirnova Galina B., Khan Irina I., Pokrovsky Vadim S., Vaneev Alexander N., Timoshenko Roman V., Mamed-Nabizade Vugara V., Zavertkina Maria V., Erofeev Alexander, Gorelkin Petr, Majouga Alexander G., Zyk Nikolay V., Khazanova Elena S., Beloglazkina Elena K.
treatment is androgen deprivation therapy, which has a wide range of side effects. One of the solutions
Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them
Machulkin A.E., Shafikov R.R., Uspenskaya A.A., Petrov S.A., Ber A.P., Skvortsov D.A., Nimenko E.A., Zyk N.U., Smirnova G.B., Pokrovsky V.S., Abakumov M.A., Saltykova I.V., Akhmirov R.T., Garanina A.S., Polshakov V.I., Saveliev O.Y., Ivanenkov Y.A., Aladinskaya A.V., Finko A.V., Yamansarov E.U., Krasnovskaya O.O., Erofeev A.S., Gorelkin P.V., Dontsova O.A., Beloglazkina E.K., Zyk N.V., Khazanova E.S., Majouga A.G.
), is a suitable target for specific delivery of antitumor drugs and diagnostic agents due to its
Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats
Tinkov A.A., Gatiatulina E.R., Popova E.V., Nikonorov A.A., Skalny A.V., Polyakova V.S., Skalnaya A.A., Agletdinov E.E.
Профориентационная и профконсультативная практика
Лытко, А.А., Такунова, Н.А.
Ultracentennial periodicity of solar activity and soil formation
Ivanov, I. V., Lisetskii, F. N.
A comparison is made of the periodicity of change in the index of soil formation and solar activity
Формирование интернациональных моделей финансового учета
Зимакова, Л. А., Костякова, Ю. В.
Бенчмаркинг российской региональной инновационной инфраструктуры
Московкин, В. М., Крымский, И. А.

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