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Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injury
Kutumova Elena O., Akberdin Ilya R., Egorova Vera S., Kolesova Ekaterina P., Parodi Alessandro, Pokrovsky Vadim S., Zamyatnin, Jr Andrey A., Kolpakov Fedor A.
Saponin is Essential for the Isolation of Proteins and RNA from Biological Nanoparticles
Brezgin Sergey, Frolova Anastasia, Bayurova Ekaterina, Slatinskaya Olga, Ponomareva Natalia, Parshina Evgeniia, Bochkova Zhanna, Kachanov Artyom, Tikhonov Andrey, Kostyusheva Anastasiya, Karandashov Ivan, Demina Polina, Latyshev Oleg, Eliseeva Olesja, Belikova Maria, Pokrovsky Vadim S., Gegechkory Vladimir, Khaydukov Evgeny, Silachev Denis, Zamyatnin Jr Andrey A., Maksimov Georgy, Lukashev Alexander, Gordeychuk Ilya, Chulanov Vladimir, Kostyushev Dmitry
for cargo extraction. Finally, we develop a unified protocol using saponin to efficiently isolate proteins
Technological aspects of manufacturing and analytical control of biological nanoparticles
Brezgin Sergey, Parodi Alessandro, Kostyusheva Anastasiya, Ponomareva Natalia, Lukashev Alexander, Sokolova Darina, Pokrovsky Vadim S., Slatinskaya Olga, Maksimov Georgy, Zamyatnin Andrey A., Chulanov Vladimir, Kostyushev Dmitry
Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment
Ponomareva Natalia, Brezgin Sergey, Karandashov Ivan, Kostyusheva Anastasiya, Demina Polina, Slatinskaya Olga, Bayurova Ekaterina, Silachev Denis, Pokrovsky Vadim S., Gegechkori Vladimir, Khaydukov Evgeny, Maksimov Georgy, Frolova Anastasia, Gordeychuk Ilya, Zamyatnin Jr. Andrey A., Chulanov Vladimir, Parodi Alessandro, Kostyushev Dmitry
their ease of functionalization, but a significant challenge arises when attempting to load therapeutic
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution
Kachanov Artyom, Kostyusheva Anastasiya, Brezgin Sergey, Karandashov Ivan, Ponomareva Natalia, Tikhonov Andrey, Lukashev Alexander, Pokrovsky Vadim, Zamyatnin Andrey A., Parodi Alessandro, Chulanov Vladimir, Kostyushev Dmitry
challenges, their clinical application has unveiled a range of limitations and safety concerns. This review
Atomic Force Microscopy: A Versatile Tool in Cancer Research
Persano F., Parodi A., Pallaeva T., Kolesova E., Zamyatnin A.A.Jr., Pokrovsky V.S., De Matteis V., Leporatti S., Cascione M.
the quantification of parameters that were previously disregarded only a few decades ago. A notable example
Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells
Chepikova O.E., Malin D., Strekalova E., Lukasheva E.V., Cryns V.L., Zamyatnin A.A.Jr.
to fundamental differences between LO and lysine depletion. LO rapidly induces ROS with a return to baseline
Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin e Conjugate
Machulkin A.E., Uspenskaya A.A., Zyk N.U., Nimenko E.A., Ber A.P., Petrov S.A., Polshakov V.I., Shafikov R.R., Skvortsov D.A., Plotnikova E.A., Pankratov A.A., Smirnova G.B., Borisova Y.A., Pokrovsky V.S., Kolmogorov V.S., Vaneev A.N., Khudyakov A.D., Chepikova O.E., Kovalev S., Erofeev A., Gorelkin P., Beloglazkina E.K., Zyk N.V., Khazanova E.S., Majouga A.G., Zamyatnin Jr A.A.
is chemotherapy, which has a wide range of side effects. One of the solutions to this challenge is targeted
In Silico, In Vitro, and Clinical Investigations of Cathepsin B and Stefin A mRNA Expression and a Correlation Analysis in Kidney Cancer
Rudzinska-Radecka M., Frolova A.S., Balakireva A.V., Gorokhovets N.V., Pokrovsky V.S., Sokolova D.V., Korolev D.O., Potoldykova N.V., Vinarov A.Z., Parodi A., Zamyatnin A.A.Jr.
The cysteine protease Cathepsin B (CtsB) plays a critical role in multiple signaling pathways
Biologics-based technologies for highly efficient and targeted RNA delivery
Kostyusheva A., Brezgin S., Ponomareva N., Frolova A., Lunin A., Bayurova E., Tikhonov A., Slatinskaya O., Demina P., Kachanov A., Babayeva G., Khan I., Khochenkov D., Khochenkova Y., Sokolova D., Silachev D., Maksimov G., Khaydukov E., Pokrovsky V.S., Zamyatnin A.A.Jr., Parodi A., Gordeychuk I., Chulanov V., Kostyushev D.
efficiency of this system in vitro and in vivo. These technologies can be adapted for manufacturing a wide

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